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BHLHA15 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q7RTS1 |
| Other Accession | NP_803238.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20818 Da |
| Antigen Region | 160-189 aa |
| Gene ID | 168620 |
|---|---|
| Other Names | Class A basic helix-loop-helix protein 15, bHLHa15, Class B basic helix-loop-helix protein 8, bHLHb8, Muscle, intestine and stomach expression 1, MIST-1, BHLHA15, BHLHB8, MIST1 |
| Target/Specificity | This BHLHA15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-189 amino acids from the C-terminal region of human BHLHA15. |
| Dilution | FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BHLHA15 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BHLHA15 |
|---|---|
| Synonyms | BHLHB8, MIST1 |
| Function | Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in brain, liver, spleen and skeletal muscle. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
References
Smits, K.M., et al. Ann Epidemiol 20(5):401-404(2010)
Tian, X., et al. Mol. Cell. Biol. 30(5):1269-1284(2010)
Stevens, J.D., et al. Differentiation 76(9):1006-1022(2008)
Zhao, Y., et al. Mol. Endocrinol. 20(9):2187-2198(2006)
McLellan, A.S., et al. Mech. Dev. 119 SUPPL 1, S285-S291 (2002) :
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