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BEX1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, E |
|---|---|
| Primary Accession | Q9HBH7 |
| Other Accession | Q9BXY8, Q2PG52, NP_060946.3 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 14860 Da |
| Antigen Region | 63-90 aa |
| Gene ID | 55859 |
|---|---|
| Other Names | Protein BEX1, Brain-expressed X-linked protein 1, BEX1 |
| Target/Specificity | This BEX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the Central region of human BEX1. |
| Dilution | IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BEX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BEX1 |
|---|---|
| Function | Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q3MKQ2}. Cytoplasm {ECO:0000250|UniProtKB:Q3MKQ2}. Note=Shuttles between the cytoplasm and the nucleus. Predominantly nuclear. {ECO:0000250|UniProtKB:Q3MKQ2} |
| Tissue Location | Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity).
References
Ding, K., et al. Carcinogenesis 30(1):35-42(2009)
Foltz, G., et al. Cancer Res. 66(13):6665-6674(2006)
Alvarez, E., et al. Gene 357(1):18-28(2005)
Quentmeier, H., et al. Leukemia 19(8):1488-1489(2005)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
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