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CLDN6 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CLDN6 Antibody (Center) AP10712C
    CLDN6 Antibody (Center) (Cat. #AP10712c) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the CLDN6 antibody detected the CLDN6 protein (arrow).
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P56747
Other Accession Q9YH90, NP_067018.2
Reactivity Human, Mouse
Predicted Zebrafish
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 23292 Da
Antigen Region 130-159 aa
Additional Information
Gene ID 9074
Other Names Claudin-6, Skullin, CLDN6
Target/Specificity This CLDN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-159 amino acids from the Central region of human CLDN6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLDN6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLDN6
Function Plays a major role in tight junction-specific obliteration of the intercellular space.
Cellular Location Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z262}. Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines
Research Areas
Citations (0)
citation

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Background

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

References

Wu, Q., et al. Eur. J. Cancer Prev. 19(3):186-194(2010)
Kleinschmidt-DeMasters, B.K., et al. Am. J. Surg. Pathol. 34(3):341-354(2010)
Rendon-Huerta, E., et al. J Gastrointest Cancer 41(1):52-59(2010)
Wu, Q., et al. Zhonghua Yi Xue Za Zhi 90(6):407-412(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)

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$ 365.00
$ 140.00
Cat# AP10712C
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