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PRSS1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P07477 |
| Other Accession | NP_002760.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26558 Da |
| Antigen Region | 81-107 aa |
| Gene ID | 5644 |
|---|---|
| Other Names | Trypsin-1, Beta-trypsin, Cationic trypsinogen, Serine protease 1, Trypsin I, Alpha-trypsin chain 1, Alpha-trypsin chain 2, PRSS1, TRP1, TRY1, TRYP1 |
| Target/Specificity | This PRSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-107 amino acids from the Central region of human PRSS1. |
| Dilution | WB~~1:1000 IHC-P~~1:100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRSS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRSS1 (HGNC:9475) |
|---|---|
| Function | Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active than the two-chain form against all of these substrates. |
| Cellular Location | Secreted, extracellular space. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.
References
Joergensen, M.T., et al. Am. J. Gastroenterol. 105(8):1876-1883(2010)
Gasiorowska, A., et al. Dig. Dis. Sci. (2010) In press :
Szmola, R., et al. J. Med. Genet. 47(5):348-350(2010)
Nakanuma, S., et al. Int. J. Oncol. 36(4):793-800(2010)
Johansen, D., et al. Pancreatology 10 (2-3), 229-237 (2010) :
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