ZC4H2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q9NQZ6 |
Other Accession | Q68FG0, NP_061154.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 26244 Da |
Antigen Region | 196-224 aa |
Gene ID | 55906 |
---|---|
Other Names | Zinc finger C4H2 domain-containing protein, Hepatocellular carcinoma-associated antigen 127, ZC4H2, HCA127, KIAA1166 |
Target/Specificity | This ZC4H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the C-terminal region of human ZC4H2. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZC4H2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZC4H2 |
---|---|
Synonyms | HCA127, KIAA1166 |
Function | Plays a role in interneurons differentiation (PubMed:26056227). Involved in neuronal development and in neuromuscular junction formation. |
Cellular Location | Cytoplasm. Nucleus Postsynaptic cell membrane. Note=Upon transfection into mouse primary hippocampal neurons, localizes at excitatory, but not inhibitory, postsynaptic sites |
Tissue Location | Expressed in fetal tissues, including in brain, intestine, lung, kidney and muscle (PubMed:23623388). Isoform 1 is expressed in numerous fetal brain regions. Isoform 3 is highly expressed in numerous fetal brain regions and spinal cord (PubMed:26056227). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein contains a C4H2-type zinc finger and is thought to be involved in zinc ion binding. There are 3 isoforms produced by alternative splicing.
References
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Wang, Y., et al. J. Immunol. 169(2):1102-1109(2002)
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