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GSDMC Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, FC, E |
|---|---|
| Primary Accession | Q9BYG8 |
| Other Accession | NP_113603.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57692 Da |
| Antigen Region | 218-246 aa |
| Gene ID | 56169 |
|---|---|
| Other Names | Gasdermin-C, Melanoma-derived leucine zipper-containing extranuclear factor, GSDMC, MLZE |
| Target/Specificity | This GSDMC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 amino acids from the Central region of human GSDMC. |
| Dilution | WB~~1:2000 IHC-P~~1:50~100 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GSDMC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GSDMC {ECO:0000303|PubMed:17350798, ECO:0000312|HGNC:HGNC:7151} |
|---|---|
| Function | [Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis. |
| Cellular Location | [Gasdermin-C]: Cytoplasm, cytosol |
| Tissue Location | Expressed mainly in trachea and spleen (PubMed:11223543). In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium (PubMed:19051310). |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Birnbaum, S., et al. Nat. Genet. 41(4):473-477(2009)
Saeki, N., et al. Genes Chromosomes Cancer 48(3):261-271(2009)
Tamura, M., et al. Genomics 89(5):618-629(2007)
Watabe, K., et al. Jpn. J. Cancer Res. 92(2):140-151(2001)
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$ 365.00
$ 140.00
Cat# AP10771c
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