CO027 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
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Primary Accession | Q2M3C6 |
Other Accession | Q9N0B5, NP_689548.2 |
Reactivity | Human, Mouse |
Predicted | Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 58444 Da |
Antigen Region | 503-531 aa |
Gene ID | 123591 |
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Other Names | Transmembrane protein C15orf27, C15orf27 |
Target/Specificity | This CO027 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 503-531 amino acids from the C-terminal region of human CO027. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CO027 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TMEM266 (HGNC:26763) |
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Function | Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529). Despite the presence of a voltage- sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529). Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529). Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, dendrite Perikaryon. Note=Present in the dendrites and soma of cerebellar granule neurons, but not in their axon |
Tissue Location | Mainly expressed in the cerebellum (PubMed:25165868). Also expressed in cerebral cortex, skeletal muscle and thyroid, but at much lower levels (PubMed:25165868) |
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Provided below are standard protocols that you may find useful for product applications.
References
Zody, M.C., et al. Nature 440(7084):671-675(2006)
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