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RT34 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | P82930 |
| Other Accession | NP_076425.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25650 Da |
| Antigen Region | 4-32 aa |
| Gene ID | 65993 |
|---|---|
| Other Names | 28S ribosomal protein S34, mitochondrial, MRP-S34, S34mt, MRPS34 |
| Target/Specificity | This RT34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human RT34. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RT34 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MRPS34 |
|---|---|
| Function | Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation. |
| Cellular Location | Mitochondrion. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternate splice variants of this gene have been described but their full-length nature has not been determined.
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Zhang, Z., et al. Genomics 81(5):468-480(2003)
Ogawa, F., et al. Biochem. Biophys. Res. Commun. 300(3):789-792(2003)
Cavdar Koc, E., et al. J. Biol. Chem. 276(22):19363-19374(2001)
O'Brien, T.W., et al. J. Biol. Chem. 275(24):18153-18159(2000)
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