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UPP2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | O95045 |
| Other Accession | Q8CGR7, NP_001128570.1, NP_775491.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35527 Da |
| Antigen Region | 217-244 aa |
| Gene ID | 151531 |
|---|---|
| Other Names | Uridine phosphorylase 2, UPase 2, UrdPase 2, UPP2 |
| Target/Specificity | This UPP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-244 amino acids from the C-terminal region of human UPP2. |
| Dilution | IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UPP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UPP2 (HGNC:23061) |
|---|---|
| Function | Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (PubMed:12849978, PubMed:21855639). Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (PubMed:12849978). |
| Tissue Location | Predominantly expressed in kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose-or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.
References
Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Johansson, M. Biochem. Biophys. Res. Commun. 307(1):41-46(2003)
Russell, R.L., et al. J. Biol. Chem. 276(16):13302-13307(2001)
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