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NARS Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | O43776 |
| Other Accession | Q8BP47, Q4R4Z1, Q2KJG3, NP_004530.1 |
| Reactivity | Human |
| Predicted | Bovine, Monkey, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 62943 Da |
| Antigen Region | 24-53 aa |
| Gene ID | 4677 |
|---|---|
| Other Names | Asparagine--tRNA ligase, cytoplasmic, Asparaginyl-tRNA synthetase, AsnRS, NARS |
| Target/Specificity | This NARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human NARS. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NARS Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NARS1 (HGNC:7643) |
|---|---|
| Function | Catalyzes the attachment of asparagine to tRNA(Asn) in a two- step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:9421509, PubMed:32738225, PubMed:32788587). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:30171954, PubMed:12235211). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587). |
| Cellular Location | Cytoplasm. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases.
References
Lim, J., et al. Cell 125(4):801-814(2006)
Lehner, B., et al. Genome Res. 14(7):1315-1323(2004)
Shiba, K., et al. Nucleic Acids Res. 26(22):5045-5051(1998)
Beaulande, M., et al. Nucleic Acids Res. 26(2):521-524(1998)
Cirullo, R.E., et al. Somatic Cell Genet. 9(2):215-233(1983)
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