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RARS Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, FC, E |
|---|---|
| Primary Accession | P54136 |
| Other Accession | NP_002878.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 75379 Da |
| Antigen Region | 605-634 aa |
| Gene ID | 5917 |
|---|---|
| Other Names | Arginine--tRNA ligase, cytoplasmic, Arginyl-tRNA synthetase, ArgRS, RARS |
| Target/Specificity | This RARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 605-634 amino acids from the C-terminal region of human RARS. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RARS Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RARS1 (HGNC:9870) |
|---|---|
| Synonyms | RARS |
| Function | Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). |
| Cellular Location | Cytoplasm. Cytoplasm, cytosol |
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Provided below are standard protocols that you may find useful for product applications.
Background
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq].
References
Bottoni, A., et al. J. Cell. Physiol. 212(2):293-297(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Ling, C., et al. J. Biol. Chem. 280(41):34755-34763(2005)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
Kaminska, M., et al. Biochemistry 40(47):14309-14316(2001)
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