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ELMO2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q96JJ3 |
| Other Accession | Q8BHL5, A4FUD6, NP_877496.1, NP_573403.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 82615 Da |
| Antigen Region | 323-350 aa |
| Gene ID | 63916 |
|---|---|
| Other Names | Engulfment and cell motility protein 2, Protein ced-12 homolog A, hCed-12A, ELMO2, CED12A, KIAA1834 |
| Target/Specificity | This ELMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-350 amino acids from the Central region of human ELMO2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ELMO2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ELMO2 |
|---|---|
| Synonyms | CED12A, KIAA1834 |
| Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| Cellular Location | Cytoplasm. Cytoplasm, cytosol. Membrane |
| Tissue Location | Widely expressed, with a higher expression in skeletal muscle, kidney and placenta. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein.
References
Bento, J.L., et al. Genomics 92(4):226-234(2008)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)
Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)
Castelo, R., et al. Nucleic Acids Res. 33(6):1935-1939(2005)
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