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C15orf24 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NPA0 |
| Other Accession | Q9EP72, Q4R5V2, A5PJA8, NP_064539.1 |
| Reactivity | Mouse |
| Predicted | Bovine, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26471 Da |
| Antigen Region | 94-122 aa |
| Gene ID | 56851 |
|---|---|
| Other Names | ER membrane protein complex subunit 7, EMC7, C11orf3, C15orf24 |
| Target/Specificity | This C15orf24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-122 amino acids from the Central region of human C15orf24. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C15orf24 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EMC7 |
|---|---|
| Synonyms | C11orf3, C15orf24 |
| Function | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N- terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein |
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The exact function of C15orf24 remains unknown.
References
Domal-Kwiatkowska, D., et al. Kardiol Pol 64(11):1287-1291(2006)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
O'Brien, K.P., et al. Biochem. Biophys. Res. Commun. 273(1):90-94(2000)
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$ 365.00
$ 140.00
Cat# AP11145c
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