- CITATIONS: 1
|Application ||WB, IHC-P, FC, E|
|Calculated MW||20140 Da|
|Antigen Region||39-68 aa|
|Other Names||Insulin-like growth factor II, IGF-II, Somatomedin-A, Insulin-like growth factor II, Insulin-like growth factor II Ala-25 Del, Preptin, IGF2|
|Target/Specificity||This IGF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the Central region of human IGF2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IGF2 Antibody (Center R54) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464).|
|Tissue Location||Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.|
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Adkins, R.M., et al. Pediatr. Res. 68(5):429-434(2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Li, J., et al. Mol. Biol. Rep. (2010) In press :
Hsieh, Y.Y., et al. Anticancer Res. 30(6):2203-2208(2010)
Turan, N., et al. PLoS Genet. 6 (7), E1001033 (2010) :
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