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CPA6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N4T0 |
| Other Accession | Q5U901, NP_065094.3 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51008 Da |
| Antigen Region | 285-315 aa |
| Gene ID | 57094 |
|---|---|
| Other Names | Carboxypeptidase A6, 3417-, CPA6, CPAH |
| Target/Specificity | This CPA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-315 amino acids from the Central region of human CPA6. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CPA6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CPA6 |
|---|---|
| Synonyms | CPAH |
| Function | May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II (PubMed:18178555). Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine (PubMed:20855895). |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Expressed in the hippocampus, nucleus raphe, and cortex. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the family of carboxypeptidases, which catalyze the release of C-terminal amino acid, and have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Polymorphic variants and a reciprocal translocation t(6;8)(q26;q13) involving this gene, have been associated with Duane retraction syndrome.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Sharif, S.A., et al. Arthritis Rheum. 60(10):2902-2912(2009)
Lyons, P.J., et al. J. Biol. Chem. 283(11):7054-7063(2008)
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