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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > PRAMEF6 Antibody (C-term)
PRAMEF6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IF, FC, E |
|---|---|
| Primary Accession | Q5VXH4 |
| Other Accession | Q5TYX0, A6NMV5, NP_001010889.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54852 Da |
| Antigen Region | 395-423 aa |
| Gene ID | 440561 |
|---|---|
| Other Names | PRAME family member 6, PRAMEF6 |
| Target/Specificity | This PRAMEF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-423 amino acids from the C-terminal region of human PRAMEF6. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRAMEF6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRAMEF6 {ECO:0000303|PubMed:26138980, ECO:0000312|HGNC:HGNC:30583} |
|---|---|
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:26138980). The CRL2(PRAMEF6) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Gregory, S.G., et al. Nature 441(7091):315-321(2006)
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$ 385.00
$ 150.00
Cat# AP11418b
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