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SCEL Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, FC, IHC-P-Leica, E |
|---|---|
| Primary Accession | O95171 |
| Other Accession | NP_659001.2, NP_003834.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 77552 Da |
| Antigen Region | 260-289 aa |
| Gene ID | 8796 |
|---|---|
| Other Names | Sciellin, SCEL |
| Target/Specificity | This SCEL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-289 amino acids from the Central region of human SCEL. |
| Dilution | WB~~1:1000 IHC-P-Leica~~1:500 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SCEL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SCEL |
|---|---|
| Function | May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope. |
| Cellular Location | Cytoplasm. Membrane. Note=May become cross-linked to membrane proteins by transglutaminase |
| Tissue Location | Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined.
References
Pyle, A.L., et al. Cardiovasc. Pathol. 19 (2), E13-E20 (2010) :
Corona, W., et al. Anticancer Res. 24 (3A), 1417-1419 (2004) :
Champliaud, M.F., et al. J. Invest. Dermatol. 121(4):781-785(2003)
Champliaud, M.F., et al. Genomics 70(2):264-268(2000)
Champliaud, M.F., et al. J. Biol. Chem. 273(47):31547-31554(1998)
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