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Neuropilin-2 Antibody (C-term K813)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O60462 |
| Other Accession | NP_003863.2, NP_957719.1, NP_061004.3, NP_957718.1, NP_958436.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 104831 Da |
| Antigen Region | 798-827 aa |
| Gene ID | 8828 |
|---|---|
| Other Names | Neuropilin-2, Vascular endothelial cell growth factor 165 receptor 2, NRP2, VEGF165R2 |
| Target/Specificity | This Neuropilin-2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 798-827 amino acids from the C-terminal region of human Neuropilin-2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Neuropilin-2 Antibody (C-term K813) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NRP2 |
|---|---|
| Synonyms | VEGF165R2 |
| Function | High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. |
| Cellular Location | Membrane; Single- pass type I membrane protein |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
References
Rey-Gallardo, A., et al. Glycobiology 20(9):1139-1146(2010)
Geretti, E., et al. Mol. Cancer Res. 8(8):1063-1073(2010)
Guo-ping, W., et al. Ann Plast Surg 65(1):80-84(2010)
Nasarre, C., et al. Cell Adh Migr 3(4):383-389(2009)
Fassold, A., et al. Arthritis Rheum. 60(10):2892-2901(2009)
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