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PRSS21 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9Y6M0 |
| Other Accession | NP_659206.1, NP_006790.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34884 Da |
| Antigen Region | 165-193 aa |
| Gene ID | 10942 |
|---|---|
| Other Names | Testisin, 3421-, Eosinophil serine protease 1, ESP-1, Serine protease 21, PRSS21, ESP1, TEST1 |
| Target/Specificity | This PRSS21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-193 amino acids from the Central region of human PRSS21. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRSS21 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRSS21 |
|---|---|
| Synonyms | ESP1, TEST1 |
| Function | Could regulate proteolytic events associated with testicular germ cell maturation. |
| Cellular Location | Cell membrane; Lipid-anchor, GPI- anchor |
| Tissue Location | Expressed predominantly in premeiotic testicular germ cells, mostly late pachytene and diplotene spermatocytes |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. It is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and it may be involved in progression of testicular tumors of germ cell origin. Alternative splicing of this gene results in three transcript variants encoding three different isoforms. [provided by RefSeq].
References
Yeom, S.Y., et al. FEBS Lett. 584(8):1469-1475(2010)
Netzel-Arnett, S., et al. Biol. Reprod. 81(5):921-932(2009)
Kempkensteffen, C., et al. J. Cancer Res. Clin. Oncol. 132(12):765-770(2006)
Manton, K.J., et al. Br. J. Cancer 92(4):760-769(2005)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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