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GALNS Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IF, IHC-P, E |
|---|---|
| Primary Accession | P34059 |
| Other Accession | Q32KJ6, Q8WNQ7, Q571E4, NP_000503.1 |
| Reactivity | Human |
| Predicted | Mouse, Pig, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58026 Da |
| Antigen Region | 236-263 aa |
| Gene ID | 2588 |
|---|---|
| Other Names | N-acetylgalactosamine-6-sulfatase, Chondroitinsulfatase, Chondroitinase, Galactose-6-sulfate sulfatase, GalN6S, N-acetylgalactosamine-6-sulfate sulfatase, GalNAc6S sulfatase, GALNS |
| Target/Specificity | This GALNS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the Central region of human GALNS. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GALNS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GALNS |
|---|---|
| Cellular Location | Lysosome. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. [provided by RefSeq].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Bank, R.A., et al. Mol. Genet. Metab. 97(3):196-201(2009)
Yan, S., et al. Biopolymers 92(5):399-404(2009)
Carraresi, L., et al. Clin. Chim. Acta 397 (1-2), 72-76 (2008) :
Bhattacharyya, S., et al. J. Biol. Chem. 283(15):9523-9530(2008)
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