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SSH3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IF, FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q8TE77 |
| Other Accession | NP_060327.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 72996 Da |
| Antigen Region | 575-602 aa |
| Gene ID | 54961 |
|---|---|
| Other Names | Protein phosphatase Slingshot homolog 3, SSH-like protein 3, SSH-3L, hSSH-3L, SSH3, SSH3L |
| Target/Specificity | This SSH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-602 amino acids from the C-terminal region of human SSH3. |
| Dilution | IF~~1:10~50 FC~~1:10~50 IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SSH3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SSH3 |
|---|---|
| Synonyms | SSH3L |
| Function | Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton. Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).
References
Kousaka, K., et al. Genesis 46(5):246-255(2008)
Kligys, K., et al. J. Biol. Chem. 282(44):32520-32528(2007)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Soosairajah, J., et al. EMBO J. 24(3):473-486(2005)
Ohta, Y., et al. Genes Cells 8(10):811-824(2003)
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