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CNGA4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8IV77 |
| Other Accession | NP_001032406.1 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 65999 Da |
| Antigen Region | 131-160 aa |
| Gene ID | 1262 |
|---|---|
| Other Names | Cyclic nucleotide-gated cation channel alpha-4, Cyclic nucleotide-gated channel alpha-4, CNG channel alpha-4, CNG-4, CNG4, CNGA4 |
| Target/Specificity | This CNGA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-160 amino acids from the N-terminal region of human CNGA4. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CNGA4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNGA4 {ECO:0000303|PubMed:11764791, ECO:0000312|HGNC:HGNC:2152} |
|---|---|
| Function | Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)- dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations. |
| Cellular Location | Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q64359}; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).
References
Hofmann, F., et al. Pharmacol. Rev. 57(4):455-462(2005)
Kelliher, K.R., et al. Proc. Natl. Acad. Sci. U.S.A. 100(7):4299-4304(2003)
Bradley, J., et al. Science 294(5549):2095-2096(2001)
Munger, S.D., et al. Science 294(5549):2172-2175(2001)
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