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PRSS3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | P35030 |
| Other Accession | NP_002762.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32529 Da |
| Antigen Region | 136-163 aa |
| Gene ID | 5646 |
|---|---|
| Other Names | Trypsin-3, Brain trypsinogen, Mesotrypsinogen, Serine protease 3, Serine protease 4, Trypsin III, Trypsin IV, PRSS3, PRSS4, TRY3, TRY4 |
| Target/Specificity | This PRSS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-163 amino acids from the Central region of human PRSS3. |
| Dilution | WB~~1:1000 FC~~1:10~50 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRSS3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRSS3 |
|---|---|
| Synonyms | PRSS4, TRY3, TRY4 |
| Function | Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. |
| Cellular Location | Secreted. |
| Tissue Location | Detected in pancreas and pancreatic fluid (at protein level) (PubMed:6698368). Expressed in pancreas and brain (PubMed:8294000). Detected in ileum (PubMed:12021776) |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.
References
Jiang, G., et al. Gut 59(11):1535-1544(2010)
Nakanishi, J., et al. J. Invest. Dermatol. 130(4):944-952(2010)
Salameh, M.A., et al. J. Biol. Chem. 285(3):1939-1949(2010)
Rosendahl, J., et al. Pancreatology 10 (2-3), 243-249 (2010) :
Koistinen, H., et al. Neuroscience 160(1):97-102(2009)
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