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METTL2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IHC-P, E |
|---|---|
| Primary Accession | Q96IZ6 |
| Other Accession | Q8BMK1, Q0P5B2, Q6P1Q9, A8KBL7, NP_859076.3 |
| Reactivity | Human |
| Predicted | Zebrafish, Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43537 Da |
| Antigen Region | 329-359 aa |
| Gene ID | 339175 |
|---|---|
| Other Names | Methyltransferase-like protein 2A, 211-, METTL2A, METTL2 |
| Target/Specificity | This METTL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-359 amino acids from the C-terminal region of human METTL2. |
| Dilution | WB~~1:1000 IF~~1:10~50 IHC-P~~1:50~100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | METTL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | METTL2A {ECO:0000303|PubMed:28655767, ECO:0000312|HGNC:HGNC:25755} |
|---|---|
| Function | S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557). |
| Cellular Location | Cytoplasm. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
METTL2A is probable methyltransferase (By similarity).
References
Zody, M.C., et al. Nature 440(7087):1045-1049(2006)
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