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MOGT3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q86VF5 |
| Other Accession | NP_835470.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38730 Da |
| Antigen Region | 295-329 aa |
| Gene ID | 346606 |
|---|---|
| Other Names | 2-acylglycerol O-acyltransferase 3, Acyl-CoA:monoacylglycerol acyltransferase 3, MGAT3, Diacylglycerol O-acyltransferase candidate 7, hDC7, Diacylglycerol acyltransferase 2-like protein 7, Monoacylglycerol O-acyltransferase 3, MOGAT3, DC7, DGAT2L7 |
| Target/Specificity | This MOGT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-329 amino acids from the C-terminal region of human MOGT3. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MOGT3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MOGAT3 (HGNC:23249) |
|---|---|
| Synonyms | DC7, DGAT2L7 |
| Function | Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region |
| Tissue Location | Selectively expressed in the digestive system. Highly expressed in the ileum, and at lower level in jejunum, duodenum, colon, cecum and the rectum. Not expressed in the stomach and the esophagus and trachea. Expressed at very low level in liver |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).
References
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Cheng, D., et al. J. Biol. Chem. 278(16):13611-13614(2003)
Winter, A., et al. Cytogenet. Genome Res. 102 (1-4), 42-47 (2003) :
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