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GSR Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IF, IHC-P, WB, E |
|---|---|
| Primary Accession | P00390 |
| Other Accession | NP_000628.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56257 Da |
| Antigen Region | 380-408 aa |
| Gene ID | 2936 |
|---|---|
| Other Names | Glutathione reductase, mitochondrial, GR, GRase, GSR, GLUR, GRD1 |
| Target/Specificity | This GSR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-408 amino acids from the C-terminal region of human GSR. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GSR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GSR |
|---|---|
| Synonyms | GLUR, GRD1 |
| Function | Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol. |
| Cellular Location | [Isoform Mitochondrial]: Mitochondrion. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
References
Satoh, N., et al. Biochem. Genet. 48 (9-10), 816-821 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Moyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(3):811-821(2010)
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