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GLMN Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q92990 |
| Other Accession | Q8BZM1, NP_444504.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 68208 Da |
| Antigen Region | 498-525 aa |
| Gene ID | 11146 |
|---|---|
| Other Names | Glomulin, FK506-binding protein-associated protein, FAP, FKBP-associated protein, GLMN, FAP48, FAP68, VMGLOM |
| Target/Specificity | This GLMN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-525 amino acids from the C-terminal region of human GLMN. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GLMN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GLMN |
|---|---|
| Function | [Isoform 1]: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924). Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature (PubMed:11845407). Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281). |
| Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq].
References
Arai, T., et al. Proc. Natl. Acad. Sci. U.S.A. 100(17):9855-9860(2003)
Brouillard, P., et al. Clin. Genet. 63(5):340-351(2003)
Krummrei, U., et al. Proc. Natl. Acad. Sci. U.S.A. 100(5):2444-2449(2003)
Brouillard, P., et al. Am. J. Hum. Genet. 70(4):866-874(2002)
Grisendi, S., et al. J. Biol. Chem. 276(49):46632-46638(2001)
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