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KCNJ8 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q15842 |
| Other Accession | Q63664, P97794, NP_004973.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47968 Da |
| Antigen Region | 4-33 aa |
| Gene ID | 3764 |
|---|---|
| Other Names | ATP-sensitive inward rectifier potassium channel 8, Inward rectifier K(+) channel Kir61, Potassium channel, inwardly rectifying subfamily J member 8, uKATP-1, KCNJ8 |
| Target/Specificity | This KCNJ8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the N-terminal region of human KCNJ8. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCNJ8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNJ8 |
|---|---|
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium (PubMed:20558321, PubMed:21836131, PubMed:24700710, PubMed:28842488). Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with ABCC9 (By similarity). |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Predominantly detected in fetal and adult heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. [provided by RefSeq].
References
Medeiros-Domingo, A., et al. Heart Rhythm 7(10):1466-1471(2010)
Ellis, J.A., et al. Physiol. Genomics 40(3):184-188(2010)
Shi, W., et al. J. Biol. Chem. 285(5):3021-3029(2010)
Winkler, M., et al. J. Biol. Chem. 284(11):6752-6762(2009)
Ploug, K.B., et al. Eur. J. Pharmacol. 601 (1-3), 43-49 (2008) :
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