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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > C109B Antibody (C-term)
C109B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NWR8 |
| Other Accession | NP_060388.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39082 Da |
| Antigen Region | 291-320 aa |
| Gene ID | 55013 |
|---|---|
| Other Names | Calcium uniporter regulatory subunit MCUb, mitochondrial, MCUb, Coiled-coil domain-containing protein 109B, CCDC109B, MCUB |
| Target/Specificity | This C109B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-320 amino acids from the C-terminal region of human C109B. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C109B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MCUB {ECO:0000303|PubMed:24231807, ECO:0000312|HGNC:HGNC:26076} |
|---|---|
| Function | Negative regulator of the mitochondrial calcium uniporter (MCU), a channel that mediates calcium uptake into the mitochondrial matrix (PubMed:31533452). MCUB is required to limit mitochondrial calcium overload during stress (PubMed:31533452). Acts as a dominant- negative regulator that displaces MCU from the functional uniplex complex and thereby decreases the association of calcium sensors MICU1 and MICU2, preventing channel gating (PubMed:31533452). Mitochondrial calcium homeostasis plays key roles in mitochondrial metabolism (PubMed:31533452). Acts as an important regulator of mitochondrial metabolism in response to stress in muscle cells: induced in response to fasting, leading to restrict mitochondrial calcium uptake, resulting in reprogramming of mitochondria toward fatty acid oxidation preference (By similarity). Acts as a regulator of macrophage polarization during skeletal muscle regeneration: inhibition of mitochondrial calcium uptake drives differentiation of macrophages with anti-inflammatory profile, promoting the differentiation and fusion of satellite cells (By similarity). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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$ 150.00
$ 385.00
Cat# AP12355b
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