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MEPE Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NQ76 |
| Other Accession | NP_001171626.1, NP_001171623.1, NP_064588.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58419 Da |
| Antigen Region | 19-48 aa |
| Gene ID | 56955 |
|---|---|
| Other Names | Matrix extracellular phosphoglycoprotein, Osteoblast/osteocyte factor 45, OF45, MEPE |
| Target/Specificity | This MEPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-48 amino acids from the N-terminal region of human MEPE. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MEPE Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MEPE |
|---|---|
| Function | Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (PubMed:14962809, PubMed:19005008). Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:18162525, PubMed:19998030, PubMed:22766095). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation (PubMed:22341070). |
| Cellular Location | Secreted, extracellular space, extracellular matrix Secreted |
| Tissue Location | Detected in urine (at protein level) (PubMed:37453717). Expressed by osteoblasts (PubMed:10945470, PubMed:11414762, PubMed:15108058). Expressed by stem cells in dental pulp (PubMed:15153459). Expressed by mesenchymal cells in dental papilla and dental pulp (PubMed:18547474, PubMed:22341070). Expressed in teeth, specifically in decidious dentin (PubMed:20581062). Expressed in ondotoblasts (PubMed:12489176). Expressed in salivary glands (PubMed:15329369). Secreted from oncogenic hypophosphatemic tumors (PubMed:11414762). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
MEPE seems to play a role in mineralization.
References
Boskey, A.L., et al. Calcif. Tissue Int. 86(1):42-46(2010)
Pereira, R.C., et al. Bone 45(6):1161-1168(2009)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Rivadeneira, F., et al. Nat. Genet. 41(11):1199-1206(2009)
Marks, J., et al. J. Am. Soc. Nephrol. 19(12):2313-2320(2008)
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