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TM181 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9P2C4 |
| Other Accession | NP_065874.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55015 Da |
| Antigen Region | 112-140 aa |
| Gene ID | 57583 |
|---|---|
| Other Names | Transmembrane protein 181, TMEM181, GPR178, KIAA1423 |
| Target/Specificity | This TM181 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-140 amino acids from the N-terminal region of human TM181. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TM181 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMEM181 |
|---|---|
| Synonyms | GPR178, KIAA1423 |
| Function | Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication. |
| Cellular Location | Membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).
References
Carette, J.E., et al. Science 326(5957):1231-1235(2009)
Wollscheid, B., et al. Nat. Biotechnol. 27(4):378-386(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Wistrand, M., et al. Protein Sci. 15(3):509-521(2006)
Cheng, J., et al. Science 308(5725):1149-1154(2005)
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