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STIM2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9P246 |
| Other Accession | NP_001162588.1, NP_065911.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 83971 Da |
| Antigen Region | 98-127 aa |
| Gene ID | 57620 |
|---|---|
| Other Names | Stromal interaction molecule 2, STIM2, KIAA1482 |
| Target/Specificity | This STIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-127 amino acids from the N-terminal region of human STIM2. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STIM2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STIM2 |
|---|---|
| Synonyms | KIAA1482 |
| Function | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration |
| Tissue Location | Expressed in all tissues and tumor cell lines examined. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing.
References
Darbellay, B., et al. J. Biol. Chem. 285(29):22437-22447(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
El Boustany, C., et al. Cell Calcium 47(4):350-359(2010)
Zhou, Y., et al. J. Biol. Chem. 284(29):19164-19168(2009)
Parvez, S., et al. FASEB J. 22(3):752-761(2008)
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