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TRIM10 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TRIM10 Antibody (C-term) AP12700b
    TRIM10 Antibody (C-term) (Cat. #AP12700b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TRIM10 antibody detected the TRIM10 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UDY6
Other Accession NP_006769.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 55037 Da
Antigen Region 410-438 aa
Additional Information
Gene ID 10107
Other Names Tripartite motif-containing protein 10, B30-RING finger protein, RING finger protein 9, TRIM10, RFB30, RNF9
Target/Specificity This TRIM10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-438 amino acids from the C-terminal region of human TRIM10.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRIM10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM10
Synonyms RFB30, RNF9
Function E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647).
Cellular Location Cytoplasm
Research Areas
Citations (0)
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Background

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms.

References

Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009) :
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
Shiina, T., et al. Genetics 173(3):1555-1570(2006)
Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
Orimo, A., et al. Biochem. Biophys. Res. Commun. 276(1):45-51(2000)

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$ 182.50
$ 70.00
Cat# AP12700b
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