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SLC9A2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9UBY0 |
| Other Accession | NP_003039.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 91520 Da |
| Antigen Region | 754-783 aa |
| Gene ID | 6549 |
|---|---|
| Other Names | Sodium/hydrogen exchanger 2, Na(+)/H(+) exchanger 2, NHE-2, Solute carrier family 9 member 2, SLC9A2, NHE2 |
| Target/Specificity | This SLC9A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-783 amino acids from the C-terminal region of human SLC9A2. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC9A2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC9A2 (HGNC:11072) |
|---|---|
| Synonyms | NHE2 |
| Function | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine (PubMed:10444453, PubMed:8843774). In the distal colon, expressed along the cryptal axis (PubMed:8843774). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC9A2 is involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Son, E.J., et al. J. Cell. Biochem. 107(5):965-972(2009)
Joly, F., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1), G116-G123 (2009) :
Musch, M.W., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 296 (2), G202-G210 (2009) :
Beltran, A.R., et al. Pflugers Arch. 455(5):799-810(2008)
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