- CITATIONS: 1
|Application ||IHC-P, WB, E|
|Other Accession||Q4G072, Q8BMC0, NP_001155970.1, NP_005758.2|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||39392 Da|
|Antigen Region||106-134 aa|
|Other Names||Lysophosphatidic acid receptor 6, LPA receptor 6, LPA-6, Oleoyl-L-alpha-lysophosphatidic acid receptor, P2Y purinoceptor 5, P2Y5, Purinergic receptor 5, RB intron encoded G-protein coupled receptor, LPAR6, P2RY5|
|Target/Specificity||This LPAR6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from the Central region of human LPAR6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LPAR6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.|
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants.
Pasternack, S.M., et al. Arch. Dermatol. Res. 301(8):621-624(2009)
Yanagida, K., et al. J. Biol. Chem. 284(26):17731-17741(2009)
Tariq, M., et al. Br. J. Dermatol. 160(5):1006-1010(2009)
Shimomura, Y., et al. J. Invest. Dermatol. 129(3):622-628(2009)
Dereure, O. Ann Dermatol Venereol 135(11):794-795(2008)
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