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CTTNBP2NL Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9P2B4 |
| Other Accession | Q99LJ0, NP_061174.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 70158 Da |
| Antigen Region | 135-164 aa |
| Gene ID | 55917 |
|---|---|
| Other Names | CTTNBP2 N-terminal-like protein, CTTNBP2NL, KIAA1433 |
| Target/Specificity | This CTTNBP2NL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the N-terminal region of human CTTNBP2NL. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CTTNBP2NL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTTNBP2NL (HGNC:25330) |
|---|---|
| Synonyms | KIAA1433 |
| Function | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). |
| Cellular Location | Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q8SX68}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q99LJ0} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
CTTNBP2NL may bind to cortactin, which is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery. The striatin-interacting phosphatase and kinase (STRIPAK) complex establishes mutually exclusive interactions with either CTTNBP2 or CTTNBP2NL.
References
Goudreault, M., et al. Mol. Cell Proteomics 8(1):157-171(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
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