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SLC30A7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8NEW0 |
| Other Accession | Q5BJM8, Q9JKN1, A4IFD7, Q6NRI1, Q52KD7, NP_598003.2, NP_001138356.1 |
| Reactivity | Human |
| Predicted | Xenopus, Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41626 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 148867 |
|---|---|
| Other Names | Zinc transporter 7, ZnT-7, Solute carrier family 30 member 7, Znt-like transporter 2, SLC30A7, ZNT7, ZNTL2 |
| Target/Specificity | This SLC30A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC30A7. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC30A7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC30A7 (HGNC:19306) |
|---|---|
| Function | Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed:15525635, PubMed:15994300). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (PubMed:15525635, PubMed:15994300). |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9JKN1} Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9JKN1} Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q5BJM8}. Mitochondrion {ECO:0000250|UniProtKB:Q5BJM8} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).
References
Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)
Zhang, L.H., et al. Brain Res. Bull. 77(1):55-60(2008)
Overbeck, S., et al. J. Leukoc. Biol. 83(2):368-380(2008)
Falcon-Perez, J.M., et al. Exp. Cell Res. 313(7):1473-1483(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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