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STRN4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9NRL3 |
| Other Accession | NP_001034966.1, NP_037535.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 80596 Da |
| Antigen Region | 124-153 aa |
| Gene ID | 29888 |
|---|---|
| Other Names | Striatin-4, Zinedin, STRN4, ZIN |
| Target/Specificity | This STRN4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-153 amino acids from the N-terminal region of human STRN4. |
| Dilution | WB~~1:1000 IHC-P~~1:100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STRN4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STRN4 (HGNC:15721) |
|---|---|
| Synonyms | ZIN |
| Function | Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed:32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed:32640226). |
| Cellular Location | Cytoplasm. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
STRN4 binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Slager, S.L., et al. Cancer Epidemiol. Biomarkers Prev. 19(4):1098-1102(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Goudreault, M., et al. Mol. Cell Proteomics 8(1):157-171(2009)
Di Bernardo, M.C., et al. Nat. Genet. 40(10):1204-1210(2008)
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