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SULF2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IWU5 |
| Other Accession | Q8CFG0, NP_001155313.1, NP_061325.1, NP_940998.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 100455 Da |
| Antigen Region | 824-852 aa |
| Gene ID | 55959 |
|---|---|
| Other Names | Extracellular sulfatase Sulf-2, hSulf-2, 316-, SULF2, KIAA1247 |
| Target/Specificity | This SULF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 824-852 amino acids from the C-terminal region of human SULF2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SULF2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SULF2 |
|---|---|
| Synonyms | KIAA1247 |
| Function | Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:30788513, PubMed:35294879). |
| Cellular Location | Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VI60}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:Q8VI60}. Cell surface |
| Tissue Location | Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta |
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Provided below are standard protocols that you may find useful for product applications.
Background
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).
References
Lai, J.P., et al. Hepatology 52(5):1680-1689(2010) Ellinor, P.T., et al. Nat. Genet. 42(3):240-244(2010) Lemjabbar-Alaoui, H., et al. Oncogene 29(5):635-646(2010) Tang, R., et al. J. Biol. Chem. 284(32):21505-21514(2009) Chau, B.N., et al. Cancer Res. 69(4):1368-1374(2009)
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