NFKBIL1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IF, IHC-P, WB, E |
---|---|
Primary Accession | Q9UBC1 |
Other Accession | Q9TSV7, O88995, NP_004998.3 |
Reactivity | Human |
Predicted | Mouse, Pig |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 43257 Da |
Antigen Region | 327-356 aa |
Gene ID | 4795 |
---|---|
Other Names | NF-kappa-B inhibitor-like protein 1, Inhibitor of kappa B-like protein, I-kappa-B-like protein, IkappaBL, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1, NFKBIL1, IKBL |
Target/Specificity | This NFKBIL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 327-356 amino acids from the C-terminal region of human NFKBIL1. |
Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NFKBIL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NFKBIL1 |
---|---|
Synonyms | IKBL |
Function | Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. |
Cellular Location | Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus |
Tissue Location | Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
References
Clancy, R.M., et al. Arthritis Rheum. 62(11):3415-3424(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Owecki, M.K., et al. Pol. Merkur. Lekarski 28(167):366-370(2010)
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