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TNP2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q05952 |
| Other Accession | NP_005416.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 15641 Da |
| Antigen Region | 88-116 aa |
| Gene ID | 7142 |
|---|---|
| Other Names | Nuclear transition protein 2, TP-2, TP2, TNP2 |
| Target/Specificity | This TNP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the C-terminal region of human TNP2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TNP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNP2 |
|---|---|
| Function | Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P11101}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P11101}. Chromosome {ECO:0000250|UniProtKB:P11101}. Note=Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is mediated by IPO4. Nucleolar localization requires the protein to be phosphorylated (By similarity). {ECO:0000250|UniProtKB:P11101, ECO:0000250|UniProtKB:P11378} |
| Tissue Location | Expressed by spermatids (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.
References
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Khattri, A., et al. Int. J. Androl. (2010) In press :
Pradeepa, M.M., et al. J. Biol. Chem. 284(43):29956-29967(2009)
Cooper, J.D., et al. Nat. Genet. 40(12):1399-1401(2008)
Becker, S., et al. Andrologia 40(4):203-208(2008)
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