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RBM28 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NW13 |
| Other Accession | NP_060547.2, NP_001159607.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 85738 Da |
| Antigen Region | 62-91 aa |
| Gene ID | 55131 |
|---|---|
| Other Names | RNA-binding protein 28, RNA-binding motif protein 28, RBM28 |
| Target/Specificity | This RBM28 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the N-terminal region of human RBM28. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RBM28 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBM28 |
|---|---|
| Function | Nucleolar component of the spliceosomal ribonucleoprotein complexes. |
| Cellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:17081119, ECO:0000269|Ref.7} |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP)complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
References
Spiegel, R., et al. Eur. J. Endocrinol. 162(6):1021-1025(2010)
Nousbeck, J., et al. Am. J. Hum. Genet. 82(5):1114-1121(2008)
Damianov, A., et al. Biol. Chem. 387 (10-11), 1455-1460 (2006) :
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Scherl, A., et al. Mol. Biol. Cell 13(11):4100-4109(2002)
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