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OXA1L Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q15070 |
| Other Accession | NP_005006.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48520 Da |
| Antigen Region | 361-390 aa |
| Gene ID | 5018 |
|---|---|
| Other Names | Mitochondrial inner membrane protein OXA1L, Hsa, OXA1Hs, Oxidase assembly 1-like protein, OXA1-like protein, OXA1L |
| Target/Specificity | This OXA1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 361-390 amino acids from the C-terminal region of human OXA1L. |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OXA1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OXA1L {ECO:0000303|PubMed:9247084, ECO:0000312|HGNC:HGNC:8526} |
|---|---|
| Function | Mitochondrial membrane insertase that mediates the cotranslational insertion of integral membrane proteins into the mitochondrial inner membrane (PubMed:17936786, PubMed:33602856, PubMed:7991568). Essential for the activity and assembly of cytochrome oxidase (PubMed:17936786, PubMed:7991568). Required for the correct biogenesis of ATP synthase and complex I in mitochondria (PubMed:17936786, PubMed:7991568). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
OXA1L is required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase.
References
Haque, M.E., et al. J. Biol. Chem. 285(45):34991-34998(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Haque, M.E., et al. J. Biol. Chem. 285(36):28353-28362(2010)
Sato, T., et al. J. Biol. Chem. 284(22):14819-14827(2009)
Stiburek, L., et al. J. Mol. Biol. 374(2):506-516(2007)
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