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SNX4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | O95219 |
| Other Accession | Q91YJ2, NP_003785.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51909 Da |
| Antigen Region | 391-420 aa |
| Gene ID | 8723 |
|---|---|
| Other Names | Sorting nexin-4, SNX4 |
| Target/Specificity | This SNX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human SNX4. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SNX4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNX4 {ECO:0000303|PubMed:9819414, ECO:0000312|HGNC:HGNC:11175} |
|---|---|
| Function | Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011). Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622). |
| Cellular Location | Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC). |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. [provided by RefSeq].
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Skanland, S.S., et al. PLoS ONE 4 (6), E5935 (2009) :
Traer, C.J., et al. Nat. Cell Biol. 9(12):1370-1380(2007)
Skanland, S.S., et al. Traffic 8(3):297-309(2007)
Leprince, C., et al. J. Cell. Sci. 116 (PT 10), 1937-1948 (2003) :
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