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ZFP91 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96JP5 |
| Other Accession | Q62511, NP_444251.1 |
| Reactivity | Human, Mouse |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 63445 Da |
| Antigen Region | 216-245 aa |
| Gene ID | 80829 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase ZFP91, 632-, Zinc finger protein 757, Zinc finger protein 91 homolog, Zfp-91, ZFP91, ZNF757 |
| Target/Specificity | This ZFP91 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the Central region of human ZFP91. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZFP91 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZFP91 |
|---|---|
| Synonyms | ZNF757 |
| Function | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF- kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2.
References
Jin, H.R., et al. Biochem. Biophys. Res. Commun. 400(4):581-586(2010)
Jin, X., et al. J. Biol. Chem. 285(40):30539-30547(2010)
Kiem, H.P., et al. Exp. Hematol. 38(9):819-822(2010)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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