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SLC15A3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8IY34 |
| Other Accession | Q924V4, Q8BPX9, NP_057666.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 63560 Da |
| Antigen Region | 168-197 aa |
| Gene ID | 51296 |
|---|---|
| Other Names | Solute carrier family 15 member 3, Osteoclast transporter, Peptide transporter 3, Peptide/histidine transporter 2, SLC15A3, OCTP, PHT2, PTR3 |
| Target/Specificity | This SLC15A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the Central region of human SLC15A3. |
| Dilution | WB~~1:2000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC15A3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC15A3 (HGNC:18068) |
|---|---|
| Function | Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693, PubMed:31254495). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). |
| Cellular Location | Lysosome membrane; Multi-pass membrane protein. Endosome membrane {ECO:0000250|UniProtKB:Q8BPX9}; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC15A3 is proton oligopeptide cotransporter. Transports free histidine and certain di-and tripeptides (By similarity).
References
Daniel, H., et al. Pflugers Arch. 447(5):610-618(2004) Sakata, K., et al. Biochem. J. 356 (PT 1), 53-60 (2001) : Botka, C.W., et al. AAPS PharmSci 2 (2), E16 (2000) :
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