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PLCD1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P51178 |
| Other Accession | P10895, NP_001124436.1, NP_006216.2 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 85665 Da |
| Antigen Region | 134-163 aa |
| Gene ID | 5333 |
|---|---|
| Other Names | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase delta-1, Phosphoinositide phospholipase C-delta-1, Phospholipase C-III, PLC-III, Phospholipase C-delta-1, PLC-delta-1, PLCD1 |
| Target/Specificity | This PLCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the N-terminal region of human PLCD1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLCD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLCD1 (HGNC:9060) |
|---|---|
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:9188725). Essential for trophoblast and placental development (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (PubMed:7890667, PubMed:9188725). |
| Tissue Location | Strongly expressed in lung, liver and heart. Also expressed at least in pancreas, kidney, skeletal muscle, placenta and brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphoinositide-specific phospholipase C (PLC) acts as a signal transducer that generates 2 second messengers, diacylglycerol and inositol 1,4,5-trisphosphate, by hydrolyzing inositol phospholipids. PLC comprises a diverse family of enzymes that differ in structure and tissue distribution (Berridge, 1993 [PubMed 8381210]).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Guo, Y., et al. J. Biol. Chem. 285(32):24999-25008(2010)
Segat, L., et al. Vaccine 28(10):2201-2206(2010)
Godin, C.M., et al. Mol. Pharmacol. 77(3):388-395(2010)
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