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TAS2R1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NYW7 |
| Other Accession | NP_062545.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34333 Da |
| Antigen Region | 267-296 aa |
| Gene ID | 50834 |
|---|---|
| Other Names | Taste receptor type 2 member 1, T2R1, Taste receptor family B member 7, TRB7, TAS2R1 |
| Target/Specificity | This TAS2R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the C-terminal region of human TAS2R1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TAS2R1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TAS2R1 |
|---|---|
| Function | Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil.
References
Upadhyaya, J., et al. Biochem. Biophys. Res. Commun. 398(2):331-335(2010)
Weiss, L.A., et al. Nature 461(7265):802-808(2009)
Go, Y., et al. Genetics 170(1):313-326(2005)
Fischer, A., et al. Mol. Biol. Evol. 22(3):432-436(2005)
Zhang, Y., et al. Cell 112(3):293-301(2003)
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