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CGB/HCG-Beta Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 3
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P0DN86 |
| Other Accession | Q6NT52, NP_149133.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17739 Da |
| Antigen Region | 137-165 aa |
| Gene ID | 1082;93659;94115 |
|---|---|
| Other Names | Choriogonadotropin subunit beta, CG-beta, Chorionic gonadotrophin chain beta, CGB, CGB3 |
| Target/Specificity | This CGB/HCG-Beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-165 amino acids from the C-terminal region of human CGB/HCG-Beta. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CGB/HCG-Beta Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CGB3 |
|---|---|
| Synonyms | CGB |
| Function | Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. |
| Cellular Location | Secreted. |
| Tissue Location | High expression in the placenta throughout pregnancy. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.
References
Cole, L.A. Placenta 31(8):653-664(2010) Ra, Y.J., et al. Interact Cardiovasc Thorac Surg 11(1):114-116(2010) Verma, B., et al. J. Immunol. 184(4):2156-2165(2010) Handschuh, K., et al. Placenta 30(12):1016-1022(2009) Reisenbichler, E.S., et al. Breast J 15(5):527-530(2009)
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