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MBNL3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NUK0 |
| Other Accession | NP_001164174.1, NP_001164173.1, NP_597846.1, NP_001164175.1, NP_001164172.1, NP_060858.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38532 Da |
| Antigen Region | 251-280 aa |
| Gene ID | 55796 |
|---|---|
| Other Names | Muscleblind-like protein 3, Cys3His CCG1-required protein, Muscleblind-like X-linked protein, Protein HCHCR, MBNL3, CHCR, MBLX39, MBXL |
| Target/Specificity | This MBNL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-280 amino acids from the Central region of human MBNL3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MBNL3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MBNL3 |
|---|---|
| Synonyms | CHCR, MBLX39, MBXL |
| Function | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. |
| Cellular Location | Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts |
| Tissue Location | Highly expressed in the placenta. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described.
References
Holt, I., et al. Am. J. Pathol. 174(1):216-227(2009)
Self, J.E., et al. Mol. Vis. 12, 1211-1216 (2006) :
Ho, T.H., et al. EMBO J. 23(15):3103-3112(2004)
Squillace, R.M., et al. Dev. Biol. 250(1):218-230(2002)
Fardaei, M., et al. Hum. Mol. Genet. 11(7):805-814(2002)
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